SUPARTZ Joint Fluid Therapy was the first hyaluronic acidcommercially available for human use in treating osteoarthritis. More than 170 million SUPARTZ® injections have been sold worldwide since its introduction in Japan in 1987. This wealth of clinical experience provides you and your patients with the confidence and reliability you get when you use the world's most prescribed joint fluid therapy.
SUPARTZ is used for the treatment of pain in osteoarthritis of the knee in patients who have failed to get adequate relief from simple painkillers or from exercise and physical therapy.
SUPARTZ is a solution made of highly purified, sodium hyaluronate (hyaluronan). Hyaluronan is a natural chemical found in the body and is found in particularly high amounts in joint tissues and in the fluid (synovial fluid) that fills the joints. The body's own hyaluronan acts like a lubricant and shock absorber in synovial fluid of a healthy joint. Osteoarthritis reduces your synovial fluid's ability to protect and lubricate your joint. An injection of SUPARTZ® is administered into your knee once a week for 3 to 5 weeks (for up to a total of 5 injections), as determined by your physician.
SUPARTZ™ is a sterile, viscoelastic non-pyrogenic solution of purified, high molecular weight sodium hyaluronate (620,000-1,170,000 daltons) having a pH of 6.8-7.8. Each one mL of SUPARTZ contains 10mg of sodium hyaluronate dissolved in a physiological saline (1.0% solution). The sodium hyaluronate is extracted from chicken combs. Sodium hyaluronate is a polysaccharide containing repeating disaccharide units of glucuronic acid and N-acetylglucosamine.
INDICATIONS AND USAGE
SUPARTZ is indicated for the treatment of pain in osteoarthritis (OA) of the knee in patients who have failed to respond adequately to conservative non-pharmacologic therapy and simple analgesics, e.g., acetaminophen.
Do not administer to patients with known hypersensitivity (allergy) to sodium hyaluronate preparations.
Do not inject this product in the knees of patients with infections or skin diseases in the area of the injection site.
Do not concomitantly use disinfectants containing quaternary ammonium salts for skin preparation because sodium hyaluronate can precipitate in their presence.